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Lysate of Probiotic Lactobacillus casei DN-114 001 Ameliorates Colitis by Strengthening the Gut Barrier Function and Changing the Gut Microenvironment
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SYSNO ASEP 0371857 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lysate of Probiotic Lactobacillus casei DN-114 001 Ameliorates Colitis by Strengthening the Gut Barrier Function and Changing the Gut Microenvironment Author(s) Zákostelská, Zuzana (MBU-M) RID
Kverka, Miloslav (MBU-M) RID, ORCID
Klimešová, Klára (MBU-M) RID
Rossmann, Pavel (MBU-M)
Mrázek, Jakub (UZFG-Y) RID, ORCID
Kopečný, Jan (UZFG-Y) RID, ORCID
Hornová, Michaela (MBU-M) RID
Šrůtková, Dagmar (MBU-M) ORCID, RID
Hudcovic, Tomáš (MBU-M) RID, ORCID
Rídl, Jakub (UMG-J) ORCID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDSource Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 11 (2011), s. 1-11Number of pages 11 s. Language eng - English Country US - United States Keywords INFLAMMATORY-BOWEL-DISEASE ; DEXTRAN SULFATE SODIUM ; LACTIC-ACID BACTERIA Subject RIV EC - Immunology R&D Projects GAP304/11/1252 GA ČR - Czech Science Foundation (CSF) GD310/08/H077 GA ČR - Czech Science Foundation (CSF) GA305/08/0535 GA ČR - Czech Science Foundation (CSF) GA303/08/0367 GA ČR - Czech Science Foundation (CSF) KJB500200904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 2B06155 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NS10340 GA MZd - Ministry of Health (MZ) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z50520514 - UMG-J (2005-2011) AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000297792400027 DOI https://doi.org/10.1371/journal.pone.0027961 Annotation Probiotic bacteria can be used for the prevention and treatment of human inflammatory diseases including inflammatory bowel diseases (IBD). However, the nature of active components and exact mechanisms of this beneficial effects have not been fully elucidated. Our aim was to investigate if lysate of probiotic bacterium L. casei DN-114 001 (Lc) could decrease the severity of intestinal inflammation in a murine model of IBD.The preventive effect of oral administration of Lc significantly reduces the severity of acute dextran sulfate sodium (DSS) colitis in BALB/c but not in SCID mice. In order to analyze how this beneficial effect interferes with well-known phases of intestinal inflammation pathogenesis in vivo and in vitro, we evaluated intestinal permeability using the FITC-labeled dextran method and analysed tight junction proteins expression by immunofluorescence and PCR Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2012
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