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Focused tandem shock waves in water and their potential application in cancer treatment
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SYSNO ASEP 0369995 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Focused tandem shock waves in water and their potential application in cancer treatment Author(s) Lukeš, Petr (UFP-V) RID, ORCID
Šunka, Pavel (UFP-V) RID
Hoffer, Petr (UFP-V) RID
Stelmashuk, Vitaliy (UFP-V) RID
Beneš, J. (CZ)
Poučková, P. (CZ)
Zeman, J. (CZ)
Dibdiak, L. (CZ)
Kolářová, H. (CZ)
Tománková, K. (CZ)
Binder, S. (CZ)Source Title Proceedings of 28th International Symposium on Shock Waves. - Manchester : Springer Verlag, 2011 - ISBN 978-3-642-25687-5 Pages p-2849-p-2849 Number of pages 6 s. Publication form USB FLASH DRIVE - USB FLASH DRIVE Action International Symposium on Shock Waves/28./ Event date 17.07.2011-22.07.2011 VEvent location Manchester Country GB - United Kingdom Event type WRD Language eng - English Country GB - United Kingdom Keywords focused shock waves ; underwater discharge ; cancer treatment Subject RIV BL - Plasma and Gas Discharge Physics R&D Projects GA202/09/1151 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z20430508 - UFP-V (2005-2011) Annotation Physical principles of novel type of generator of focused tandem shock waves with time delay between the first and second shock waves of 10 µs have been presented. Generator produces at the focus strong shock wave with peak positive pressure up to 80 MPa followed by tensile wave with peak negative pressure down up to -80 MPa, generating thus at the focus a large number of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of acute lymphoblastic leukemia cells, and on tumor growth delay experiments ex vivo and in vivo. Synergetic cytotoxicity of FTSW with Photosan on tumor growth was observed, possibly due to cavitation induced sonodynamic effect of FTSW. Workplace Institute of Plasma Physics Contact Vladimíra Kebza, kebza@ipp.cas.cz, Tel.: 266 052 975 Year of Publishing 2012
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