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Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma
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SYSNO ASEP 0369516 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma Author(s) Santarelli, L. (IT)
Strafella, E. (IT)
Staffolani, S. (IT)
Amati, M. (IT)
Emanuelli, M. (IT)
Sartini, D. (IT)
Pozzi, V. (IT)
Carbonari, D. (IT)
Bracci, M. (IT)
Pignotti, E. (IT)
Mazzanti, P. (IT)
Sabbatini, A. (IT)
Ranaldi, R. (IT)
Gasparini, S. (IT)
Neužil, Jiří (BTO-N) RID
Tomasetti, M. (IT)Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 6, č. 4 (2011), e18232Number of pages 9 Language eng - English Country US - United States Keywords Malignant pleural mesothelioma ; microRNAs ; soluble mesothelin-related peptides Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/08/0811 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000289058300007 DOI 10.1371/journal.pone.0018232 Annotation Improved detection methods for diagnosis of malignant mesothelioma (MM) are essential for detection and treatment. miRNAs isolated from fresh-frozen biopsies of MM patients were tested for the expression of 88 types of miRNA involved in cancerogenesis. Three significantly downregulated miRNAs were assayed in cancerous tissue and adjacent non-cancerous tissue sample pairs collected from 27 formalin-fixed, paraffin-embedded MM tissues by quantitative RT-PCR. Only miR-126 remained downregulated in the malignant tissues. The performance of the selected miR-126 as biomarker was evaluated in serum samples of asbestos-exposed subjects and MM patients and compared with controls. MiR-126 was not affected by asbestos exposure, whereas it was found associated with VEGF serum levels. Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MM, SMRPs, correlate with subjects at high risk to develop MM. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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