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Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain
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SYSNO ASEP 0369481 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain Author(s) Rohlena, Jakub (BTO-N) RID, ORCID
Dong, L.-F. (AU)
Ralph, S.J. (AU)
Neužil, Jiří (BTO-N) RIDSource Title Antioxidants & Redox Signaling. - : Mary Ann Liebert - ISSN 1523-0864
Roč. 15, č. 12 (2011), s. 2951-2974Number of pages 24 Language eng - English Country US - United States Keywords Targets for anticancer drugs ; mitochondrial electron transport chain ; mitocans Subject RIV EB - Genetics ; Molecular Biology R&D Projects KAN200520703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000296588900004 DOI 10.1089/ars.2011.3990 Annotation A group of compounds that induce mitochondrial destabilization affecting the physiology of cancer cells has been defined and termed 'mitocans.' We have placed these agents into several groups including hexokinase inhibitors, compounds targeting Bcl-2 proteins, thiol redox inhibitors, VDAC/ANT targeting drugs, electron transport chain-targeting drugs, lipophilic cations targeting the inner membrane, agents affecting the TCA cycle and drugs targeting mtDNA. Mitocans have a potential to prove efficient in suppressing various malignant diseases in a selective manner. They include compounds that offer promise to become clinically applied drugs. We redefine the individual classes of mitocans, providing examples of the various members of groups with a focus on agents targeting the electron transport chain. Even though ROS induction is important for the anticancer activity of many mitocans, the precise sequence of events is not yet fully clarified, and warrants further investigation. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
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