Number of the records: 1
Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal
- 1.0369475 - FGÚ 2012 RIV NL eng J - Journal Article
Ujčíková, Hana - Dlouhá, Kateřina - Roubalová, Lenka - Vošahlíková, Miroslava - Kagan, Dmytro - Svoboda, Petr
Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.
Biochimica et Biophysica Acta-General Subjects. Roč. 1810, č. 12 (2011), s. 1220-1229. ISSN 0304-4165. E-ISSN 1872-8006
R&D Projects: GA MŠMT(CZ) LC554; GA MŠMT(CZ) LC06063; GA ČR(CZ) GD305/08/H037
Institutional research plan: CEZ:AV0Z50110509
Keywords : morphine * long-term adaptation * adenylyl cyclase isoforms I–IX * forebrain cortex * isolated plasma membranes
Subject RIV: FH - Neurology
Impact factor: 5.000, year: 2011
We assume that the specific increase in expression level of ACI and ACII in brain cortex of morphine-adapted rats proceeds as a compensatory, homeostatic response to prolonged exposure to inhibitory drug, morphine. Our findings demonstrate that the dramatic and specific change of the crucial component of the opioid receptor cascade in brain cortex, manifested as an increase in PM level of ACI and II, is reversible
Permanent Link: http://hdl.handle.net/11104/0203528
Number of the records: 1