Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex

0369361 - BÚ 2012 RIV GB eng J - Journal Article
Nosál´ová, G. - Capek, P. - Flešková, D. - Jureček, L´. - Hindák, F. - Lukavský, Jaromír - Cepák, Vladislav - Ray, B. - Breierová, E. - Turjan, J.
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.
International Journal of Biological Macromolecules. Roč. 49, č. 4 (2011), 1046-1050. ISSN 0141-8130. E-ISSN 1879-0003
R&D Projects: GA MŠMT 1M0571
Institutional research plan: CEZ:AV0Z60050516
Keywords : Rhodella griesea * proteoglykan * cough
Subject RIV: EF - Botanics
Impact factor: 2.453, year: 2011

An algal extracellular biopolymer (over 8.5 × 105 Da) composed of carbohydrates (52%) and protein (13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (63%), galactose (12%), glucuronic acid (11–12%), glucose (5%), rhamnose (4%), fucose (3–4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.
Permanent Link: http://hdl.handle.net/11104/0203444