Number of the records: 1
The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply
- 1.
SYSNO ASEP 0369317 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The influence of a subanaesthetic dose of ketamine on circulating pro-inflammatory cytokines and serotonin in brain reply Author(s) Horáček, J. (CZ)
Tejkalová, H. (CZ)
Novák, T. (CZ)
Bubeníková-Valešová, V. (CZ)
Páleníček, T. (CZ)
Rambousek, L. (CZ)
Růžičková, Šárka (BTO-N) RID
Vaculín, Š. (CZ)
Hoeschl, C. (CZ)Source Title Psychological Medicine. - : Cambridge University Press - ISSN 0033-2917
Roč. 41, č. 8 (2011), s. 1787-1789Number of pages 3 s. Language eng - English Country US - United States Keywords serotonin ; proinflammatory ; cytokines Subject RIV AN - Psychology CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000292704400022 Annotation Psychiatric diseases are associated with elevated levels of pro-inflammatory cytokines in affected patients. Cytokines IL-1 and TNF- enhance the production of serotonin transporter (5-HT) thus, antidepressants could mediate their effect by downregulation of these cytokines. Therefore, we studied the influence of ketamine in male Wistar/Hann rats on IL-1 and TNF- and 5-HT activity in the blood and brain. Both cytokines increased up to 140% and 150% only in control animals, not in the ketamine group. Ketamine administration led to lower 5-HT levels in the hippocampus compared to controls (t=2.218, p<0.05). The hippocampal 5-HT levels correlated negatively with the basal TNF- and positively with the absolute and relative change of this cytokine in the whole sample, which suggests inhibition of IL-1 and TNF-activity. The mechanisms responsible for the interaction between the pro-inflammatory pathway, 5-HT and antidepressant effect of ketamine remain unknown Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2012
Number of the records: 1