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Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]
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SYSNO ASEP 0368775 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] Author(s) Westendorf, A.F. (DE)
Zerzánková, Lenka (BFU-R)
Salassa, L. (GB)
Sadler, P.J. (GB)
Brabec, Viktor (BFU-R) RID, ORCID
Bednarski, P.J. (DE)Number of authors 6 Source Title Journal of Inorganic Biochemistry. - : Elsevier - ISSN 0162-0134
Roč. 105, č. 5 (2011), s. 652-662Number of pages 11 s. Language eng - English Country US - United States Keywords platinum azides ; cisplatin ; photoactivation Subject RIV BO - Biophysics R&D Projects IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GD301/09/H004 GA ČR - Czech Science Foundation (CSF) GAP301/10/0598 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000290923100009 DOI 10.1016/j.jinorgbio.2011.01.003 Annotation The photocytotoxicity and photobiochemical properties of the new complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)(piperidine)] are compared with its analogue containing the less basic and less lipophilic ligand pyridine. The results indicate that the piperidine complex has a more rapid rate of light activation to cytotoxic species but in other cellular and biochemical aspects its behavior is similar to that of pyridine analogue. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2012
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