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Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study
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SYSNO ASEP 0368688 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study Author(s) Noristani, H. N. (GB)
Meadows, R. S. (GB)
Olabarria, M. (GB)
Verkhratsky, Alexei (UEM-P)
Rodríguez Arellano, Jose Julio (UEM-P)Source Title Cell Death & Disease. - : Springer - ISSN 2041-4889
Roč. 2, - (2011), e210Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords Alzheimer's disease ; serotonin ; serotonin transporter Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) GAP304/11/0184 GA ČR - Czech Science Foundation (CSF) GA309/08/1381 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000295404600014 EID SCOPUS 80053425131 DOI 10.1038/cddis.2011.79 Annotation Here, we analysed the ultrastructural localisation, distribution and numerical density of hippocampal SERT axons (SERT-Ax) and terminals (SERT-Te) and their relationship with SERT fibre sprouting and altered synaptic density in 3xTg-AD compared with non-transgenic control mice. Our results suggested that concomitant increase in density of serotonergic terminals and reduction in the number of perforated axospinous synapses in 3xTg-AD mice (a model of Alzheimer’s disease) may act as a compensatory mechanism maintaining synaptic efficacy as a response to the AD cognitive impairment. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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