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Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1
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SYSNO ASEP 0368598 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1 Author(s) Maj, J. (PL)
Morzycki, J.W. (PL)
Rárová, Lucie (UEB-Q) RID, ORCID
Oklešťková, Jana (UEB-Q) RID, ORCID, SAI
Strnad, Miroslav (UEB-Q) RID, ORCID
Wojtkielewicz, A. (PL)Number of authors 6 Source Title Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623
Roč. 54, č. 9 (2011), s. 3298-3305Number of pages 8 s. Language eng - English Country US - United States Keywords POTENT ANTITUMOR SAPONIN ; CHOLESTANE GLYCOSIDES ; ORNITHOGALUM-SAUNDERSIAE ; SIDE-CHAINS ; AGLYCONE Subject RIV EF - Botanics R&D Projects GA301/08/1649 GA ČR - Czech Science Foundation (CSF) ED0007/01/01 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000290126800014 DOI 10.1021/jm101648h Annotation Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2012
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