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Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis
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SYSNO ASEP 0368248 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis Author(s) Forostyak, Serhiy (UEM-P) RID, ORCID
Jendelová, Pavla (UEM-P) RID, ORCID
Kapcalová, Miroslava (UEM-P)
Arboleda Toro, David (UEM-P)
Syková, Eva (UEM-P) RIDSource Title Cytotherapy. - : Elsevier - ISSN 1465-3249
Roč. 13, č. 9 (2011), s. 1036-1046Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords motor neurons ; neurodegenerative diseases ; stem cells Subject RIV FH - Neurology R&D Projects LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP304/11/0189 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000294904300003 DOI 10.3109/14653249.2011.592521 Annotation In current study transgenic rats overexpressing mutant human SOD1 were used as a model of fALS. We have found that grafting of MSC into symptomatic rats had a significant effect on motor activity and grip strength and longer lifespan if compared with the control group of animals. Transplanted cells survived and migrated in the spinal cord until the end stage of the disease without any side effects. Combined delivery of BM-derived MSC, therefore, could be an attractive approach for bench-to bedside studies in the treatment of ALS. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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