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Do clones degenerate over time? Explaining the genetic variability of asexuals through population genetic models
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SYSNO ASEP 0368204 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Do clones degenerate over time? Explaining the genetic variability of asexuals through population genetic models Author(s) Janko, Karel (UZFG-Y) RID, ORCID
Drozd, P. (CZ)
Eisner, Jan (BC-A)Number of authors 3 Source Title Biology Direct
Roč. 6, č. 17 (2011), s. 1-25Number of pages 25 s. Language eng - English Country GB - United Kingdom Keywords MITOCHONDRIAL-DNA VARIATION ; MULLERS RATCHET ; LOACHES COBITIS Subject RIV EB - Genetics ; Molecular Biology R&D Projects GP206/05/P586 GA ČR - Czech Science Foundation (CSF) GA206/09/1298 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000288783800001 DOI 10.1186/1745-6150-6-17 Annotation Background: Quest for understanding the nature of mechanisms governing the life span of clonal organisms lasts for several decades. Phylogenetic evidence for recent origins of most clones is usually interpreted as proof that clones suffer from gradual age-dependent fitness decay (e.g. Muller's ratchet). However, we have shown that a neutral drift can also qualitatively explain the observed distribution of clonal ages. This finding was followed by several attempts to distinguish the effects of neutral and non-neutral processes. Most recently, Neiman et al. 2009 (Ann N Y Acad Sci.: 1168:185-200.) reviewed the distribution of asexual lineage ages estimated from a diverse array of taxa and concluded that neutral processes alone may not explain the observed data. Moreover, the authors inferred that similar types of mechanisms determine maximum asexual lineage ages in all asexual taxa. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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