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Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites
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SYSNO ASEP 0367760 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites Author(s) Kořený, Luděk (BC-A) RID
Sobotka, Roman (MBU-M) RID, ORCID
Janouškovec, J. (CZ)
Keeling, P. J. (CA)
Oborník, Miroslav (BC-A) RID, ORCIDSource Title Plant Cell. - : Oxford University Press - ISSN 1040-4651
Roč. 23, č. 9 (2011), s. 3454-3462Number of pages 10 s. Language eng - English Country US - United States Keywords YEAST SACCHAROMYCES-CEREVISIAE ; HEME-BIOSYNTHESIS PATHWAY ; PLASMODIUM-FALCIPARUM ; MALARIA PARASITE ; 5-AMINOLEVULINATE SYNTHASE ; SECONDARY PLASTIDS ; TOXOPLASMA-GONDII ; PROTEIN-TRANSPORT ; EUGLENA-GRACILIS ; METABOLIC MAPS Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA206/08/1423 GA ČR - Czech Science Foundation (CSF) IAA601410907 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000296739100030 DOI 10.1105/tpc.111.089102 Annotation Most photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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