Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

Lake, A.D.; Novák, Petr; Fisher, C.D.; Jackson, J.P.; Hardwick, R.N.; Billheimer, D.D.; Klimecki, W.T.; Cherrington, N.J.

doi:https://dx.doi.org/10.1124/dmd.111.040592

Number of the records: 1

Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease

1.

SYSNO ASEP	0367248
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Analysis of Global and Absorption, Distribution, Metabolism, and Elimination Gene Expression in the Progressive Stages of Human Nonalcoholic Fatty Liver Disease
Author(s)	Lake, A.D. (US) Novák, Petr (BC-A)_{RID, ORCID} Fisher, C.D. (US) Jackson, J.P. (US) Hardwick, R.N. (US) Billheimer, D.D. (US) Klimecki, W.T. (US) Cherrington, N.J. (US)
Number of authors	8
Source Title	Drug Metabolism and Disposition - ISSN 0090-9556 Roč. 39, č. 10 (2011), s. 1954-1960
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	Steatosis ; Steatohepatitis ; Nonalcoholic fatty liver disease
Subject RIV	EB - Genetics ; Molecular Biology
CEZ	AV0Z50510513 - UMBR-M, BC-A (2005-2011)
UT WOS	000295026600023
DOI	10.1124/dmd.111.040592
Annotation	Nonalcoholic fatty liver disease (NAFLD) is characterized by a series of pathological changes that range from simple fatty liver to nonalcoholic steatohepatitis (NASH). The objective of this study is to describe changes in global gene expression associated with the progression of human NAFLD. This study is focused on the expression levels of genes responsible for the absorption, distribution, metabolism, and elimination (ADME) of drugs. Differential gene expression between three clinically defined pathological groups-normal, steatosis, and NASH-was analyzed.The results suggest that uptake transporter genes are coordinately targeted for down-regulation at the global level during the pathological development of NASH and that these patients may have decreased drug uptake capacity. This coordinated regulation of uptake transporter genes is indicative of a hepatoprotective mechanism acting to prevent accumulation of toxic intermediates in disease-compromised hepatocytes.
Workplace	Biology Centre (since 2006)
Contact	Dana Hypšová, eje@eje.cz, Tel.: 387 775 214
Year of Publishing	2012

Number of the records: 1