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Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly
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SYSNO ASEP 0366666 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly Author(s) Breton, M. (FR)
Berret, J. - F. (FR)
Bourgaux, C. (FR)
Kral, Teresa (UFCH-W) RID, ORCID
Hof, Martin (UFCH-W) RID, ORCID
Pichon, Ch. (FR)
Bessodes, M. (FR)
Scherman, D. (FR)
Mignet, N. (FR)Source Title Langmuir. - : American Chemical Society - ISSN 0743-7463
Roč. 27, č. 20 (2011), s. 12336-12345Number of pages 9 s. Language eng - English Country US - United States Keywords fluorescence correlation spectroscopy ; angle neutron-scattering ; bilayer thickness Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects IAA400400621 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06063 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000295665400013 DOI 10.1021/la202439s Annotation We assessed in this work how a chemical structure difference could influence a supramolecular organization and then its biological properties. In our case study, we considered two amphiphilic lipidic gene vectors. The chemical difference was situated on their hydrophilic part which was either a pure neutral thiourea head or a mixture of three thiourea function derivatives, thiourea, iminothiol, and charged iminothiol. This small difference was obtained thanks to the last chemical deprotection conditions of the polar head hydroxyl groups. Light, neutron, and X-ray scattering techniques have been used to investigate the spatial structure of the liposomes and lipoplexes formed by the lipids. The chemical structure difference impacts the supramolecular assemblies of the lipids and with DNA as shown by fluorescence correlation spectroscopy (FCS), X-ray, and neutron scattering. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2012
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