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Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells
- 1.0366512 - BFÚ 2012 RIV IE eng J - Journal Article
Umannová, Lenka - Machala, M. - Topinka, Jan - Schmuczerová, Jana - Krčmář, P. - Neča, J. - Šujanová, Klára - Kozubík, Alois - Vondráček, Jan
Benzo[a]pyrene and tumor necrosis factor-alpha coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.
Toxicology Letters. Roč. 206, č. 2 (2011), s. 121-129. ISSN 0378-4274. E-ISSN 1879-3169
R&D Projects: GA ČR(CZ) GAP503/11/1227
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702; CEZ:AV0Z50390512; CEZ:AV0Z50390703
Keywords : DNA adducts * proinflammatory cytokines * COX-2
Subject RIV: BO - Biophysics
Impact factor: 3.230, year: 2011
In the present study, we report data showing that a proinflammatory cytokine and environmentally-relevant polycyclic aromatic hydrocarbon interact to potentiate both DNA damage and the inflammatory response in alveolar epithelial type II cells, which may occur through coordinated upregulation of p38 MAP kinase activity.
Permanent Link: http://hdl.handle.net/11104/0201482
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