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The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors
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SYSNO ASEP 0366424 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors Author(s) Procházková, Jiřina (BFU-R) RID, ORCID
Kabátková, Markéta (BFU-R) ORCID
Bryja, Vítězslav (BFU-R) RID, ORCID
Umannová, Lenka (BFU-R)
Bernatík, O. (CZ)
Kozubík, Alois (BFU-R) RID, ORCID
Machala, M. (CZ)
Vondráček, Jan (BFU-R) RID, ORCIDNumber of authors 8 Source Title Toxicological Sciences. - : Oxford University Press - ISSN 1096-6080
Roč. 122, č. 2 (2011), s. 349-360Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords dioxin ; beta-catenin ; AhR Subject RIV BO - Biophysics R&D Projects GD204/09/H058 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000293914500011 DOI 10.1093/toxsci/kfr129 Annotation Beta-catenin is a key integrator of cadherin-mediated cell-cell adhesion and transcriptional regulation through the Wnt/beta-catenin pathway, which plays an important role in liver biology. In the present study, we showed that, although beta-catenin may augment the expression of selected target genes of the AhR, a transcriptional factor mediating toxic effects of persistent organic pollutants, the AhR activation may lead to downregulation of Wnt/beta-catenin signaling, and alterations in differentiation and/or proliferative status of liver progenitor cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2012
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