0366082 - BFÚ 2012 RIV GB eng J - Journal Article
Kočí, Lenka - Hýžďalová, Martina - Vaculová, Alena - Hofmanová, Jiřina - Kozubík, Alois
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial.
Cytokine. Roč. 55, č. 1 (2011), s. 34-39. ISSN 1043-4666. E-ISSN 1096-0023
R&D Projects: GA ČR(CZ) GA524/07/1178; GA ČR(CZ) GA301/07/1557; GA ČR(CZ) GD303/09/H048; GA ČR(CZ) GA305/09/1526
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : TRAIL * anoikis * PI3K/Akt pathway
Subject RIV: BO - Biophysics
Impact factor: 3.019, year: 2011

The resistance of transformed epithelial cells to a detachment-induced apoptosis (anoikis) can significantly affect their susceptibility to anticancer therapy. We showed that detachment of both fetal (FHC) and adenocarcinoma (HT-29) human colon epithelial cells resulted in the activation of the pro-survival Akt pathway, and significant changes in integrin-linked kinase (ILK) and focal adhesive kinase (FAK) phosphorylation. Our results may have important implications for optimization of new strategies in treatment of cancers at different stages of development.
Permanent Link: http://hdl.handle.net/11104/0201173