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Cysteine proteases from bloodfeeding arthropod ectoparasites
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SYSNO ASEP 0365983 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cysteine proteases from bloodfeeding arthropod ectoparasites Author(s) Sojka, Daniel (BC-A) RID, ORCID
Francischetti, I.M.B. (US)
Calvo, E. (US)
Kotsyfakis, Michalis (BC-A) RID, ORCIDSource Title Advances in Experimental Medicine and Biology - ISSN 0065-2598
Roč. 712, - (2011), s. 177-191Number of pages 15 s. Language eng - English Country US - United States Keywords TICK HAEMAPHYSALIS-LONGICORNIS ; PROLIXUS STAL HEMIPTERA ; YELLOW-FEVER MOSQUITO ; BLOOD-MEAL DIGESTION ; L-LIKE ENZYME ; BOOPHILUS-MICROPLUS ; RHODNIUS-PROLIXUS ; CATHEPSIN-B ; ASPARAGINYL ENDOPEPTIDASES/LEGUMAINS ; PROTEOLYTIC ACTIVATION Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600960910 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA600960811 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KJB600960911 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000289378600011 DOI 10.1007/978-1-4419-8414-2_11 Annotation Cysteine proteases have been discovered in various bloodfeeding ectoparasites. Here, we assemble the available information about the function of these peptidases and reveal their role in hematophagy and parasite development. While most of the data shed light on key proteolytic events that play a role in arthropod physiology, we also report on the association of cysteine proteases with arthropod vectorial capacity. With emphasis on ticks, specifically Ixodes ricinus, we finally propose a model about the contribution of cysteine peptidases to blood digestion and how their concerted action with other tick midgut proteases leads to the absorbance of nutrients by the midgut epithelial cells. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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