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Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes
- 1.0365887 - BFÚ 2012 RIV US eng J - Journal Article
Cang, X. - Šponer, Jiří - Cheatham III, T.E.
Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes.
Nucleic Acids Research. Roč. 39, č. 10 (2011), s. 4499-4512. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : quantum chemistry * DNA * quadruplex
Subject RIV: BO - Biophysics
Impact factor: 8.026, year: 2011
Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn.
Permanent Link: http://hdl.handle.net/11104/0201027
Number of the records: 1