Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic

0365854 - ÚEM 2012 RIV NL eng J - Journal Article
Rössner ml., Pavel - Uhlířová, Kateřina - Beskid, Olena - Rössnerová, Andrea - Švecová, Vlasta - Šrám, Radim
Expression of XRCC5 in peripheral blood lymphocytes is upregulated in subjects from a heavily polluted region in the Czech Republic.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 713, 1-2 (2011), s. 76-82. ISSN 0027-5107
R&D Projects: GA MŽP(CZ) SP/1B3/8/08; GA MŠMT 2B08005
Institutional research plan: CEZ:AV0Z50390512
Keywords : oxidative stress * chromosomal aberrations * gene expression
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 2.850, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0365854_01.pdf

The levels of oxidative stress markers [8-oxodG, 15-F2t-IsoP, protein carbonyls] and cytogenetic parameters [FG/100, %AB.C., and (ace)] in subjects living in Prague (N=64) and in the heavily polluted Ostrava region (N=75) were investigated. Despite the fact, that the levels of air pollutants were significantly higher in Ostrava vs. Prague, neither differences in biomarkers of oxidative stress or in cytogenetic parameters between these two locations were found. Subjects living in Ostrava has increased odds of having above-median levels of XRCC5 expression. Above-median levels of 8-oxodG were associated with decreased levels of vitamin C and E, which were elevated in subjects from Ostrava. It may be concluded, that air pollution by c-PAHs affects XRCC5 gene expression, which probably protects subjects from Ostrava against the induction of a higher frequency of translocations, and elevated vitamin C and E levels decrease the levels of 8-oxodG.
Permanent Link: http://hdl.handle.net/11104/0201000