Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons

Andrysík, Zdeněk; Vondráček, Jan; Marvanová, S.; Ciganek, M.; Neča, J.; Pěnčíková, K.; Mahadevan, B.; Topinka, Jan; Baird, W.M.; Kozubík, Alois; Machala, M.

doi:https://dx.doi.org/10.1016/j.mrfmmm.2011.06.011

Number of the records: 1

Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons

1.

SYSNO ASEP	0365816
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: The role of polycyclic aromatic hydrocarbons
Author(s)	Andrysík, Zdeněk (BFU-R) Vondráček, Jan (BFU-R)_{RID, ORCID} Marvanová, S. (CZ) Ciganek, M. (CZ) Neča, J. (CZ) Pěnčíková, K. (CZ) Mahadevan, B. (US) Topinka, Jan (UEM-P)_{RID, ORCID} Baird, W.M. (US) Kozubík, Alois (BFU-R)_{RID, ORCID} Machala, M. (CZ)
Number of authors	11
Source Title	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107 Roč. 714, 1-2 (2011), s. 53-62
Number of pages	10 s.
Language	eng - English
Country	NL - Netherlands
Keywords	urban air pollution ; PAHs ; AhR
Subject RIV	BO - Biophysics
R&D Projects	GA310/07/0961 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
	AV0Z50390512 - UEM-P (2005-2011)
	AV0Z50390703 - UEM-P (2007-2013)
UT WOS	000294937700007
DOI	10.1016/j.mrfmmm.2011.06.011
Annotation	In the present study we used an organic extract of the urban dust standard reference material, SRM1649a, as a model mixture to study a range of toxic effects related to DNA damage and AhR activation. We found that this extract, as well as its neutral and polar fractions, were potent inducers of a range of AhR-mediated responses. Importantly, these toxic events occurred at doses one order of magnitude lower than induction of DNA damage. Our data suggested that more attention should be paid to the AhR-dependent nongenotoxic events elicited by urban air particulate matter constituents, especially polycyclic aromatic hydrocarbons and their derivatives.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1