Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

McDermott-Roe, Ch.; Ye, J.; Ahmed, R.; Sun, X. M.; Serafín, A.; Ware, J.; Bottolo, L.; Muckett, P.; Caňas, X.; Zhang, J.; Rowe, G. C.; Buchan, R.; Lu, H.; Braithwaite, A.; Mancini, M.; Hauton, D.; Martí, R.; García-Arumí, E.; Hubner, N.; Jacob, H.; Serikawa, T.; Zídek, Václav; Papoušek, František; Kolář, František; Cardona, M.; Ruiz-Meana, M.; García-Dorado, D.; Comella, J. X.; Felkin, L. E.; Barton, P. J. R.; Arany, Z.; Pravenec, Michal; Petretto, E.; Sanchis, D.; Cook, S.A.

doi:https://dx.doi.org/10.1038/nature10490

Number of the records: 1

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function

1.

SYSNO ASEP	0365728
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
Author(s)	McDermott-Roe, Ch. (GB) Ye, J. (ES) Ahmed, R. (GB) Sun, X. M. (GB) Serafín, A. (ES) Ware, J. (GB) Bottolo, L. (GB) Muckett, P. (GB) Caňas, X. (ES) Zhang, J. (ES) Rowe, G. C. (US) Buchan, R. (GB) Lu, H. (GB) Braithwaite, A. (GB) Mancini, M. (IT) Hauton, D. (GB) Martí, R. (ES) García-Arumí, E. (ES) Hubner, N. (DE) Jacob, H. (US) Serikawa, T. (JP) Zídek, Václav (FGU-C)_RID Papoušek, František (FGU-C) Kolář, František (FGU-C)_{RID, ORCID, SAI} Cardona, M. (ES) Ruiz-Meana, M. (ES) García-Dorado, D. (ES) Comella, J. X. (ES) Felkin, L. E. (GB) Barton, P. J. R. (GB) Arany, Z. (US) Pravenec, Michal (FGU-C)_{RID, ORCID} Petretto, E. (GB) Sanchis, D. (ES) Cook, S.A. (GB)
Source Title	Nature. - : Palgrave Macmillan - ISSN 0028-0836 Roč. 478, č. 7367 (2011), s. 114-118
Number of pages	5 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	left ventricular hypertrophy ; endonuclease G ; mitochondrial dysfunction
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA301/08/0166 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000295575400045
DOI	https://doi.org/10.1038/nature10490
Annotation	Left ventricular mass (LVM) is a highly heritable trait and an independent risk factor for all-cause mortality. We identified mutation in endonuclease G (Endog) that is associated with increased LVM and impaired cardiac function. Our study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2012

Number of the records: 1