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Preclinical Evaluation of (177)Lu-Nimotuzumab: A Potential Tool for Radioimmunotherapy of Epidermal Growth Factor Receptor-Overexpressing Tumors
- 1.0365501 - ÚJF 2012 RIV US eng J - Journal Article
Beckford, Denis R. - Eigner, Sebastian - Beran, Miloš - Eigner-Henke, Kateřina - Lázníček, M. - Melichar, František - Chinol, M.
Preclinical Evaluation of (177)Lu-Nimotuzumab: A Potential Tool for Radioimmunotherapy of Epidermal Growth Factor Receptor-Overexpressing Tumors.
Cancer Biotherapy and Radiopharmaceuticals. Roč. 26, č. 3 (2011), s. 287-297. ISSN 1084-9785. E-ISSN 1557-8852
R&D Projects: GA MŠMT OE08018
Institutional research plan: CEZ:AV0Z10480505
Keywords : EGFR * (177)Lu * monoclonal antibodies * Nimotuzumab
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 1.787, year: 2011
Background: The humanized monoclonal antibody Nimotuzumab (h-R3) has demonstrated an exceptional and better clinical profile than other monoclonal antibodies for immunotherapy of epidermal growth factor receptor-overexpressing tumors. This work deals with the preparation and radiolabeling optimization of (177)Lu-Nimotuzumab and their preclinical evaluation. Methods: Nimotuzumab was conjugated with S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (p-SCN-Bn-DOTA), testing different molar ratios. The immunoconjugates were characterized. The radiolabeling with (177)Lu was optimized.
Permanent Link: http://hdl.handle.net/11104/0200730
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