Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions

Macková, Hana; Proks, Vladimír; Horák, Daniel; Kučka, Jan; Trchová, Miroslava

doi:https://dx.doi.org/10.1002/pola.24930

Number of the records: 1

Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions

1.

SYSNO ASEP	0365161
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions
Author(s)	Macková, Hana (UMCH-V)_RID Proks, Vladimír (UMCH-V)_{RID, ORCID} Horák, Daniel (UMCH-V)_{RID, ORCID} Kučka, Jan (UMCH-V)_{RID, ORCID} Trchová, Miroslava (UMCH-V)_{RID, ORCID}
Source Title	Journal of Polymer Science. Part A - Polymer Chemistry. - : WILEY-BLACKWELL - ISSN 0887-624X Roč. 49, č. 22 (2011), s. 4820-4829
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	click chemistry ; magnetic ; microspheres
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	KJB400500904 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	KAN401220801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GAP503/10/0664 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000296255900013
DOI	10.1002/pola.24930
Annotation	Magnetic poly(N-propargylacrylamide) (PPRAAm) microspheres were prepared by the precipitation polymerization of N-propargylacrylamide in a toluene/propan-2-ol medium in the presence of magnetic nanoparticles. The effects of polymerization parameters, including the polarity of the medium, polymerization temperature, the concentration of monomer, and the amount of magnetite in the polymerization feed, were examined. The microspheres were characterized in terms of their morphology, size, distribution, and iron content using TEM, SEM and AAS. As expected, Oleic acid-coated Fe3O4 nanoparticles contributed to the stabilization of the magnetic microspheres. Alkyne groups in magnetic PPRAAm microspheres were detected by IR. Microspheres were used as the anchor to enable a ‘‘click’’ reaction with an azido-end-functionalized model peptide (radiolabeled azidopentanoyl-GGGRGDSGGGY(125I)-NH2) and 4-azidophenylalanine using a Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction in water.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2012

Number of the records: 1