The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis

0365137 - ÚTIA 2012 RIV DK eng J - Journal Article
Luchavová, M. - Zikán, V. - Michalská, D. - Raška, I. - Kuběna, Aleš Antonín - Štěpán, J. J.
The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis.
European Journal of Endocrinology. Roč. 164, č. 4 (2011), s. 643-648. ISSN 0804-4643. E-ISSN 1479-683X
Grant - others:GA MZd(CZ) NS10564
Institutional research plan: CEZ:AV0Z10750506
Keywords : intact parathyroid-hormone * serum cortisol * diurnal rhythm * growth-hormone * in-vivo * resorption * osteoprotegerin * calcium * abnormalities * osteocalcin
Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
Impact factor: 3.423, year: 2011
http://library.utia.cas.cz/separaty/2011/E/kubena-the effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis.pdf

We hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover. The concentration of serum C-terminal telopeptide of collagen type I (beta CTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3 h over a 24 h period in 14 postmenopausal osteoporotic women (aged 72.4 +/- 9.3 years) treated with 20 mu g TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.
Permanent Link: http://hdl.handle.net/11104/0200452