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Association between Va166Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients
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SYSNO ASEP 0364541 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Association between Va166Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients Author(s) Šerý, Omar (UZFG-Y) RID
Šťastný, F. (CZ)
Zvolský, P. (CZ)
Hlinomazová, Z. (CZ)
Balcar, V. J. (AU)Number of authors 5 Source Title Neuroscience Letters. - : Elsevier - ISSN 0304-3940
Roč. 499, č. 3 (2011), s. 154-157Number of pages 4 s. Language eng - English Country IE - Ireland Keywords Glutamate ; GABA ; Retina Subject RIV FH - Neurology CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000294087800003 DOI 10.1016/j.neulet.2011.05.038 Annotation Brain-derived neurotrophic factor (BDNF) is a protein encoded, in humans, by BDNF gene on chromosome U. BDNF protects adult neurons and promotes growth and differentiation during ontogenetic development but the nature and magnitude of its effects could be influenced by functional polymorphisms. The BDNF polymorphism Va166Met (rs6265) has been studied in the context of etiology of mental diseases including alcoholism. Alcoholism - a complex disorder known to be linked to several genes - has multiple manifestations, including sensory deficits such as those affecting vision. In the present study we examined a relationship between the Va166Met polymorphism, alcohol dependence and colour vision deficiency (CVD) in 167 alcohol-dependent men and 289 control male subjects. Statistical analysis revealed that almost half (about 48%) of the alcohol dependent men had a CVD. In addition we found that CVD was significantly associated (P = 0.005) with the Va166Met polymorphism. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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