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Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids
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SYSNO ASEP 0364489 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids Author(s) Flachs, Pavel (FGU-C) RID
Rühl, R. (HU)
Hensler, Michal (FGU-C)
Janovská, Petra (FGU-C) RID, ORCID
Zouhar, Petr (FGU-C) RID, ORCID, SAI
Kůs, Vladimír (FGU-C)
Macek Jílková, Zuzana (FGU-C)
Papp, E. (HU)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Svobodová, Michaela (FGU-C) RID, ORCID
Rossmeisl, Martin (FGU-C) RID, ORCID
Tsenov, Grygoriy (FGU-C) RID, ORCID
Mohamed-Ali, V. (GB)
Kopecký, Jan (FGU-C) RID, ORCIDSource Title Diabetologia - ISSN 0012-186X
Roč. 54, č. 10 (2011), s. 2626-2638Number of pages 13 s. Language eng - English Country DE - Germany Keywords 15-Deoxy-Delta(12,15)-prostaglandin J(2) ; DHA ; EPA ; fish oil ; white adipose tissue ; metabolic syndrome Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects 1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA303/08/0664 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000294683000019 DOI 10.1007/s00125-011-2233-2 Annotation White adipose tissue plays an active role in the amelioration of obesity and the improvement of glucose homeostasis by combining LC n-3 PUFA intake and calorie restriction in mice fed high-fat diet. Specifically in the epididymal fat in the abdomen, but not in other fat depots, synergistic induction of mitochondrial oxidative capacity and lipid catabolism was observed, resulting in increased oxidation of metabolic fuels in the absence of mitochondrial uncoupling, while low-grade inflammation was suppressed, reflecting changes in tissue levels of anti-inflammatory lipid mediators, namely 15-Deoxy-∆12,15-prostaglandin J2 and protectin D1 Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2012
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