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Electrochemical quantification of 2,6-diisopropylphenol (propofol)
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SYSNO ASEP 0363717 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electrochemical quantification of 2,6-diisopropylphenol (propofol) Author(s) Langmaier, Jan (UFCH-W) RID, ORCID, SAI
Garay, F. (US)
Kivlehan, F. (US)
Chaum, E. (US)
Lindner, E. (US)Source Title Analytica Chimica Acta. - : Elsevier - ISSN 0003-2670
Roč. 704, 1-2 (2011), s. 63-67Number of pages 5 s. Language eng - English Country NL - Netherlands Keywords electrochemistry ; 2,6-diisopropylphenol ; propofol Subject RIV CG - Electrochemistry CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000296824600006 DOI 10.1016/j.aca.2011.08.003 Annotation 2,6-Diisopropylphenol (propofol) is a potent anesthetic drug with fast onset of the anesthetic effect and short recovery time for the patients. Outside of the United States, propofol is widely used in performing target controlled infusion anesthesia. With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution. When the electrochemical oxidation of propofol takes place on a glassy carbon working electrode, an electrochemically active film grows on the electrode surface. The reduction current of the film is proportional to the propofol concentration and the accumulation time. Based on these findings a stripping analytical method was developed for the detection of propofol in acidic solutions between 0 and 30 μM, with a detection limit of 5.5±0.4 μM. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2012
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