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Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity
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SYSNO ASEP 0361235 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: Efficient synthesis and antiviral activity Author(s) Hocková, Dana (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)
Andrei, G. (BE)
Snoeck, R. (BE)
Balzarini, J. (BE)Number of authors 5 Source Title Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 19, č. 15 (2011), s. 4445-4453Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords drug design ; purines ; pyrimidines Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP207/11/0108 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000292913400004 DOI 10.1016/j.bmc.2011.06.045 Annotation Series of novel acyclic nucleoside phosphonates with various nucleobases and 2-(2-phosphonoethoxy)ethyl chain bearing various substituents in beta-position to the phosphonate moiety were prepared. The influence of structural alternations on antiviral activity was studied. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
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