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A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates
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SYSNO ASEP 0360949 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates Author(s) Beier, Petr (UOCHB-X) RID, ORCID
Opekar, Stanislav (UOCHB-X)
Zibinsky, M. (US)
Bychinskaya, I. (US)
Prakash, G. K. S. (US)Number of authors 5 Source Title Organic & Biomolecular Chemistry. - : Royal Society of Chemistry - ISSN 1477-0520
Roč. 9, č. 11 (2011), s. 4035-4038Number of pages 4 s. Language eng - English Country GB - United Kingdom Keywords fluorine ; phosphonate ; alkylation Subject RIV CC - Organic Chemistry R&D Projects GP203/08/P310 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000290735300008 DOI 10.1039/c1ob05095h Annotation A new route to alpha-alkyl-alpha-fluoromethylenebisphosphonates (2) has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either cesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important alpha-alkyl-alpha-fluoromethylenebisphosphonic acid (3), while alkoxide–induced carbon–phosphorus bond cleavage of 2 gave alfa-fluorophosphonates (4), which are useful synthons in organic synthesis. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
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