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Results and Problems in Cell Differentiation
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SYSNO ASEP 0360511 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title The Role of RanGTP Gradient in Vertebrate Oocyte Maturation Author(s) Kalab, P. (US)
Šolc, Petr (UZFG-Y) RID, ORCID
Motlík, Jan (UZFG-Y) RID, ORCIDNumber of authors 3 Source Title Results and Problems in Cell Differentiation. - Heidelberg : Springer, 2011 - ISBN 978-3-642-19065-0 Pages s. 235-267 Number of pages 33 s. Number of copy 1000 Number of pages 588 Language eng - English Country DE - Germany Keywords RanGTP ; Oocyte Subject RIV EB - Genetics ; Molecular Biology R&D Projects GC301/09/J036 GA ČR - Czech Science Foundation (CSF) ME08030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000292219600012 DOI 10.1007/978-3-642-19065-0_12 Annotation The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase has an essential role in relaying the active role of chromosomes in their own segregation by the meiotic process. In addition to its conserved role as a key regulator of macromolecular transport between nucleus and cytoplasm, Ran has important functions during cell division, including in mitotic spindle assembly and in the assembly of nuclear envelope at the exit from mitosis. The cellular functions of Ran are mediated by RanGTP interactions with nuclear transport receptors (NTRs) related to importin b and depend on the existence of chromosome-centered RanGTP gradient. Live imaging with FRET biosensors indeed revealed the existence of RanGTP gradient throughout mouse oocyte maturation. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
Number of the records: 1