HVRII of mtDNA in Cord Blood Cells of Newborn Children and in Their Saliva 10 Years Later

0360462 - ÚEM 2012 RIV CZ eng J - Journal Article
Schmuczerová, Jana - Töröková, P. - Kujanová, M. - Čechová, H. - Topinka, Jan - Dostál, Miroslav - Šrám, Radim - Brdička, R.
HVRII of mtDNA in Cord Blood Cells of Newborn Children and in Their Saliva 10 Years Later.
Folia Biologica. Roč. 56, č. 1 (2011), s. 26-29. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MŽP SL/5/160/05
Institutional research plan: CEZ:AV0Z50390512
Keywords : mitochondrial DNA * cord blood * saliva
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 1.151, year: 2011
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0360462_01.pdf

Comparison of hypervariable region II nucleotide sequences of mitochondrial DNA obtained from cord blood cells and saliva cells of the same individual at birth and after ten years showed a few differences at the co-called mutation hot spots (three transitions and three indels within the C-tract). The personal identity of samples was proved by short tandem repeat profiling. Comparison of individuals living in two regions with different air pollution, however, did not reveal statistically significantly increased number of mutations in the population from the region of poorer environmental conditions, although indicating such tendency.
Permanent Link: http://hdl.handle.net/11104/0198012