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Adenosine and ATP Receptors in the Brain
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SYSNO ASEP 0360461 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Adenosine and ATP Receptors in the Brain Author(s) Burnstock, G. (GB)
Fredholm, B. B. (SE)
Verkhratsky, Alexei (UEM-P)Source Title Current Topics in Medicinal Chemistry. - : Bentham Science Publishers - ISSN 1568-0266
Roč. 11, č. 8 (2011), s. 973-1011Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords Ischaemia ; CNS ; glia Subject RIV FH - Neurology R&D Projects GA309/08/1381 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000289773500005 DOI 10.2174/156802611795347627 Annotation Here we review a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells; the role of P1 and P2 receptors in neurone-glia interactions, in presynaptic neuromodulation (P1 receptors), in fast synaptic transmission and synaptic plasticity (P2X receptors) and in presynaptic activities (P2Y receptors). Purinergic signalling is involved in neuropathology , such as Parkinson's disease and epilepsy, trauma, ischaemia. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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