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Guanidinium Cations Pair with Positively Charged Arginine Side Chains in Water
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SYSNO ASEP 0360095 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Guanidinium Cations Pair with Positively Charged Arginine Side Chains in Water Author(s) Kubíčková, A. (CZ)
Křížek, T. (CZ)
Coufal, P. (CZ)
Wernersson, Erik (UOCHB-X)
Heyda, Jan (UOCHB-X)
Jungwirth, Pavel (UOCHB-X) RID, ORCIDNumber of authors 6 Source Title Journal of Physical Chemistry Letters. - : American Chemical Society - ISSN 1948-7185
Roč. 2, č. 12 (2011), s. 1387-1389Number of pages 3 s. Language eng - English Country US - United States Keywords guanidinium ; cations ; arginine ; electrophoresis ; water Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA203/08/0114 GA ČR - Czech Science Foundation (CSF) LC512 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000291781700008 DOI 10.1021/jz2005495 Annotation Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2012
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