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Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes
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SYSNO ASEP 0359971 Document Type C - Proceedings Paper (int. conf.) R&D Document Type Conference Paper Title Voltammetric determination of anticancer drug flutamide at screen-printed carbon electrodes Author(s) Vyskočil, V. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Barek, J. (CZ)Source Title Sborník přednášek. XXXI. Moderní elektrochemické metody. - Ústí nad Labem : BEST servis, 2011 / Navrátil Tomáš ; Barek J. - ISBN 978-80-254-9634-3 Pages s. 190-194 Number of pages 5 s. Action Moderní elektrochemické metody /31./ Event date 23.05.2011-27.05.2011 VEvent location Jetřichovice Country CZ - Czech Republic Event type WRD Language eng - English Country CZ - Czech Republic Keywords creatine ; screen-printed carbon electrodes ; flutamide Subject RIV CG - Electrochemistry R&D Projects IAA400400806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GAP206/11/1638 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000304395000042 Annotation Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide, is the active component of a synthetic nonsteroidal antiandrogen drug, which is commonly used in the treatment of advanced prostate cancer. In this contribution, optimum conditions have been found vor voltammetric determination of flutamide by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at screen-printed carbon electrodes (SPCEs). Under optimum conditions (Britton-Robinson buffer pH 7.0 - methanol (9:1)), linear calibration curves were measure with limits of quantification 6x10(-7) molL(-1) and 8x10(-7) molL(-1) for DCV at SPCEs, respectively. The newly developed methods were successfully applied to the determination of the drug in pharmaceutical formulation Apo-Flutamide (Eulexin tablets). Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2012
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