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Astroglial networks scale synaptic activity and plasticity
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SYSNO ASEP 0359930 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Astroglial networks scale synaptic activity and plasticity Author(s) Pannasch, U. (FR)
Vargová, Lýdia (UEM-P) RID
Reingruber, J. (FR)
Ezan, P. (FR)
Holcman, D. (FR)
Giaume, C. (FR)
Syková, Eva (UEM-P) RID
Rouach, N. (FR)Source Title Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
Roč. 108, č. 20 (2011), s. 8467-8472Number of pages 6 s. Language eng - English Country US - United States Keywords hippocampus ; neuroglial interactions Subject RIV FH - Neurology R&D Projects MEB021140 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000290719600076 DOI 10.1073/pnas.1016650108 Annotation Using mice deficient for connexin 30 and 43, the study show that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. By controlling synaptic strength, connexins play an important role in synaptic plasticity. The results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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