Number of the records: 1  

Astroglial networks scale synaptic activity and plasticity

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    SYSNO ASEP0359930
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleAstroglial networks scale synaptic activity and plasticity
    Author(s) Pannasch, U. (FR)
    Vargová, Lýdia (UEM-P) RID
    Reingruber, J. (FR)
    Ezan, P. (FR)
    Holcman, D. (FR)
    Giaume, C. (FR)
    Syková, Eva (UEM-P) RID
    Rouach, N. (FR)
    Source TitleProceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences - ISSN 0027-8424
    Roč. 108, č. 20 (2011), s. 8467-8472
    Number of pages6 s.
    Languageeng - English
    CountryUS - United States
    Keywordshippocampus ; neuroglial interactions
    Subject RIVFH - Neurology
    R&D ProjectsMEB021140 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z50390512 - UEM-P (2005-2011)
    UT WOS000290719600076
    DOI10.1073/pnas.1016650108
    AnnotationUsing mice deficient for connexin 30 and 43, the study show that astroglial networks tone down hippocampal synaptic transmission in CA1 pyramidal neurons. Gap junctional networking facilitates extracellular glutamate and potassium removal during synaptic activity through modulation of astroglial clearance rate and extracellular space volume. By controlling synaptic strength, connexins play an important role in synaptic plasticity. The results establish connexins as critical proteins for extracellular homeostasis, important for the formation of functional synapses.
    WorkplaceInstitute of Experimental Medicine
    ContactLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Year of Publishing2012
Number of the records: 1  

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