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Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections
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SYSNO ASEP 0359447 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Activated CD8+T cells contribute to clearance of gastric Cryptosporidium muris infections Author(s) Kváč, Martin (BC-A) RID, RID, ORCID
Lӧvy, Alena (BC-A) RID
Sak, Bohumil (BC-A) RID, ORCID
Květoňová, Dana (BC-A) SAI
Jalovecká, M. (CZ)
Rost, M. (CZ)
Salát, Jiří (BC-A) RID, ORCIDSource Title Parasite immunology. - : Wiley - ISSN 0141-9838
Roč. 33, č. 4 (2011), 210-216Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords CD4+T-lymphocytes ; CD8+T-lymphocytes ; Cryptosporidium muris ; T-cell-mediated immunity Subject RIV EC - Immunology R&D Projects KJB500960701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000288249400002 DOI 10.1111/j.1365-3024.2010.01271.x Annotation The role of CD4+ and CD8+ T lymphocytes in the development of a protective immune response against Cryptosporidium muris infection was studied by the reconstitution of severe combined immunodeficient (SCID) mice with well-defined populations of either naive or immune CD8+ or CD4+ T lymphocytes. Adoptive transfer of both naive and immune CD4+ T lymphocyte subpopulations protects SCID mice against cryptosporidiosis. Moreover, a significant biological impact of activated CD8+ T cells against gastric cryptosporidiosis was observed. Thus, although CD4+ T cells are considered important in protective immunity, our results are the first to demonstrate the involvement of activated CD8+ T lymphocytes in the protection of mice against gastric cryptosporidiosis. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2012
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