Hyaluronan minimizes effects of UV irradiation on human keratinocytes

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SYSNO ASEP	0359410
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Hyaluronan minimizes effects of UV irradiation on human keratinocytes
Author(s)	Hašová, M. (CZ) Crhák, Tomáš (BFU-R) Šafaříková, Barbora (BFU-R) Dvořáková, J. (CZ) Muthný, T. (CZ) Velebný, V. (CZ) Kubala, Lukáš (BFU-R)_{RID, ORCID}
Number of authors	7
Source Title	Archives of Dermatological Research. - : Springer - ISSN 0340-3696 Roč. 303, č. 4 (2011), s. 277-284
Number of pages	8 s.
Language	eng - English
Country	DE - Germany
Keywords	hyaluronan ; keratinocyte ; ultraviolet light
Subject RIV	BO - Biophysics
R&D Projects	GA305/08/1704 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000289728300007
DOI	10.1007/s00403-011-1146-8
Annotation	Exposure to ultraviolet (UV) irradiation has detrimental effects on skin accompanied by the increased metabolism of hyaluronan (HA). Immortalized human keratinocytes (HaCaT) were irradiated by a single dose of UVB and immediately treated with HA for 6 and 24 h. The expressions of HA synthase-3 and hyaluronidase-3 were not significantly odulated by UV irradiation. In contrast, HA significantly suppressed UVB-induced proinflammatory cytokine release including interleukin-6 and interleukin-8.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2012

Number of the records: 1