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Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s
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SYSNO ASEP 0359220 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enzymatic degradation of the hydrogels based on synthetic poly(.alpha.-amino acid)s Author(s) Sedlačík, Tomáš (UMCH-V) RID
Studenovská, Hana (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDSource Title Journal of Materials Science-Materials in Medicine. - : Springer - ISSN 0957-4530
Roč. 22, č. 4 (2011), s. 781-788Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords PHEG and copolymers ; poly(alpha-amino acid)s ; hydrogels Subject RIV CD - Macromolecular Chemistry R&D Projects 1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) KJB400500801 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GP203/04/P124 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000290044000004 DOI 10.1007/s10856-011-4275-x Annotation Biodegradable hydrogels are studied as potential scaffolds for soft tissue regeneration. In this work biodegradable hydrogels were prepared from synthetic poly (a-amino acid)s, poly(AA)s. The covalently crosslinked gels were formed by radical copolymerization of methacryloylated poly(AA)s, e.g. poly[N5-(2-hydroxy-ethyl)-L-Glu- ran-L-Ala-ran-N6-methacryloyl-L-Lys], as a multifunctional macromer with a low-molecular-weight methacrylic monofunctional monomer, e.g. HEMA. Due to their polypeptide backbone, synthetic poly(AA)s are cleavable in biological environment by enzyme-catalyzed hydrolysis. The feasibility of enzymatic degradation of poly(AA)s alone and the hydrogels made from them was studied using elastase, a matrix proteinase involved in tissue healing processes, as a model enzyme. Specificity of elastase for cleavage of polypeptide chains behind the L-Ala residues was reflected in faster degradation of L-Ala-containing copolymers as well as of hydrogels composed of them. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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