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Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery
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SYSNO ASEP 0358505 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery Author(s) Angelova, A. (FR)
Angelov, Borislav (UMCH-V) RID
Mutafchieva, R. (BG)
Lesieur, S. (FR)
Couvreur, P. (FR)Source Title Accounts of Chemical Research. - : American Chemical Society - ISSN 0001-4842
Roč. 44, č. 2 (2011), s. 147-156Number of pages 10 s. Language eng - English Country US - United States Keywords lipid-water phases ; liquid crystals ; multicompartment lipid nanostructures Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA202/09/2078 GA ČR - Czech Science Foundation (CSF) GAP208/10/1600 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000287263700007 DOI 10.1021/ar100120v Annotation Lipids and lipopolymers self-assembled into biocompatible nano and mesostructured functional materials offer many potential applications in medicine and diagnostics. In this Account, it is demonstrated how high-resolution structural investigations of bicontinuous cubic templates made from lyotropic thermosensitive liquid-crystalline (LC) materials have initiated the development of innovative lipidopolymeric self-assembled nanocarriers. Such structures have tunable nanochannel sizes, morphologies, and hierarchical inner organizations and provide potential vehicles for the predictable loading and release of therapeutic proteins, peptides, or nucleic acids. This Account shows that structural studies of swelling of bicontinuous cubic lipid/water phases are essential for overcoming the nanoscale constraints for encapsulation of large therapeutic molecules in multicompartment lipid carriers. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2012
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