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Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines
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SYSNO ASEP 0357898 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines Author(s) Gucký, Tomáš (UEB-Q) ORCID
Řezníčková, Eva (UEB-Q) RID, ORCID
Džubák, P. (CZ)
Hajdúch, M. (CZ)
Kryštof, Vladimír (UEB-Q) RID, ORCIDSource Title Monatshefte fur Chemie. - : Springer - ISSN 0026-9247
Roč. 141, č. 6 (2010), s. 709-714Number of pages 6 s. Language eng - English Country AT - Austria Keywords Pyrazolo[4,3-e][1,2,4]triazine ; Anticancer ; Cyclin-dependent kinase Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/08/0511 GA ČR - Czech Science Foundation (CSF) GA301/08/1649 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000278470600016 DOI 10.1007/s00706-010-0314-4 Annotation The deregulation of cell cycle components in cancer cells has provided a rationale for the development of small molecule inhibitors of cyclin-dependent kinases as novel anticancer drugs. A series of 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines was synthesized and their kinase inhibitory activity and cytotoxicity against several cancer cell lines has been evaluated. Some of the compounds of the series exhibited induction of caspase-dependent cell death and inhibition of cyclin-dependent kinase 2 (CDK2). Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2011
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