Number of the records: 1
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease
- 1.
SYSNO ASEP 0357625 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease Author(s) Rodríguez Arellano, Jose Julio (UEM-P)
Witton, J. (GB)
Olabarria, M. (GB)
Noristani, H. N. (GB)
Verkhratsky, Alexei (UEM-P)Source Title Cell Death & Disease. - : Springer - ISSN 2041-4889
Roč. 1, č. 1 (2010), e1-e6Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords microglia ; Alzheimer´s disease ; hippocampus Subject RIV FH - Neurology R&D Projects GA309/09/1696 GA ČR - Czech Science Foundation (CSF) GA305/08/1384 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000279616300001 EID SCOPUS 77949491472 DOI 10.1038/cddis.2009.2 Annotation Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular Aβ accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular Aβ load that is characteristic of the terminal stages of the disease. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2011
Number of the records: 1