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Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material
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SYSNO ASEP 0356676 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material Author(s) Sperlingova, I. (CZ)
Dabrowská, L. (CZ)
Stránský, V. (CZ)
Duskova, S. (CZ)
Kučera, Jan (UJF-V) RID, ORCID, SAI
Tvrdíková, M. (CZ)
Tichý, M. (CZ)Source Title Analytical and Bioanalytical Chemistry. - : Springer - ISSN 1618-2642
Roč. 397, č. 2 (2010), s. 433-438Number of pages 6 s. Action 12th International Symposium on Biological and Environmental Reference Materials Keble Coll Event date 07.07.2009-10.07.2009 VEvent location Oxford Country GB - United Kingdom Event type EUR Language eng - English Country DE - Germany Keywords Candidate reference material ; Ethylene glycol monobutyl ether ; Metabolite Subject RIV BG - Nuclear, Atomic and Molecular Physics, Colliders CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000276768400004 DOI 10.1007/s00216-009-3148-3 Annotation Ethylene glycol monobutyl ether (EGBE), an industrial solvent, is absorbed by the body not only by inhalation but also by dermal absorption (liquid or vapour). EGBE is metabolized to butoxyacetic acid (BAA). Pooled freeze-dried urine candidate reference material (RM) was prepared from urine obtained from persons occupationally exposed to EGBE. This material has the advantage of containing butoxyacetic acid in both the free and conjugated (glutamine and glycine) forms, as found in native urine. In all GC method modifications used, acid hydrolysis was used to release BAA from its conjugated form. The amount of butoxyacetic acid in homogeneity and stability testing was measured by GC after derivatisation with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide. Detection was by MS in EI mode, in the authors' laboratory. For interlaboratory comparison of the reference material GC methods with MS, FID, and ECD were used. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2011
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