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The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
- 1.0356171 - FGÚ 2011 RIV GB eng J - Journal Article
Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
Biochemical Journal. Roč. 433, č. 1 (2011), s. 197-204. ISSN 0264-6021. E-ISSN 1470-8728
R&D Projects: GA ČR(CZ) GA305/06/0319; GA ČR GAP301/10/1159; GA AV ČR(CZ) IAA600110701; GA MŠMT(CZ) LC554; GA MŠMT(CZ) 1M0517
Grant - others:GA MŠk(CZ) LC06010; GA MŠk(CZ) SVV-2010-261304
Program: LC
Institutional research plan: CEZ:AV0Z50110509; CEZ:AV0Z60870520
Keywords : ankyrin receptor * transient receptor channel * voltage sensor
Subject RIV: FH - Neurology
Impact factor: 4.897, year: 2011
The ankyrin transient receptor potential channel TRPA1 is a nonselective cationic channel that is expressed by sensory neurons, where it can be activated by pungent chemicals, such as allyl isothiocyanate (AITC) or highly depolarizing voltages (> +100 mV). In this study, we mutated 27 basic residues all along the C-terminal tail of TRPA1 and explored their role in AITC and voltage-dependent gating. We identify basic residues in the C-terminus that are strongly involved in TRPA1 voltage and chemical sensitivity, some of them may represent possible interaction sites for negatively charged molecules that are generally considered to modulate TRPA1
Permanent Link: http://hdl.handle.net/11104/0194765
Number of the records: 1