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Cytokines shape chemotherapy-induced and 'bystander' senescence
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SYSNO ASEP 0353769 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cytokines shape chemotherapy-induced and 'bystander' senescence Author(s) Hodný, Zdeněk (UMG-J) RID
Hubáčková, Soňa (UMG-J) RID
Bártek, Jiří (UMG-J) RIDSource Title Aging. - : Impact Journals LLC - ISSN 1945-4589
Roč. 2, č. 2 (2010), s. 375-376Number of pages 2 s. Language eng - English Country US - United States Keywords bystander cellular senescence ; cytokines ; PML Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA204/08/1418 GA ČR - Czech Science Foundation (CSF) GA301/08/0353 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000281873900001 Annotation In this short summary we discuss our recently published data about the newly emerging role of autocrine and paracrine cytokine signaling pathways in development of senescent phenotype in perspective of other data reported. DNA damage response activated by chronic subtoxic stresses leads to expression of cytokine encoding genes either primarily due to DNA damage activated kinases and/or secondarily through autocrine and paracrine effects of secreted cytokines, which activate network of cytokine-driven signaling pathways such as JAK/STAT. Changed gene expression pattern of senescent cells includes several tumor suppressors such as interferons, PML, STAT and IRF1. Intriguingly, persistent exposition of cells to conditioned media of chemotherapy-induced senescent cells is able to evoke premature senescence in neighbouring 'bystanding' cells. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2011
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