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Inhibition of human thymidine phosphorylase by phosphonate analogues of pyrimidine nucleoside 2’(3’)-phosphates
- 1.0353488 - ÚOCHB 2011 FR eng C - Conference Paper (international conference)
Panova, Natalya - Markusová Kóšiová, Ivana - Šimák, Ondřej - Petrová, Magdalena - Liboska, Radek - Buděšínský, Miloš - Rejman, Dominik - Rosenberg, Ivan
Inhibition of human thymidine phosphorylase by phosphonate analogues of pyrimidine nucleoside 2’(3’)-phosphates.
International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon: Université de Lyon, 2010, s. 336-337.
[International Roundtable on Nucleosides, Nucleotides and Nucleic Acids. IRT 2010. Lyon (FR), 29.08.2010-03.09.2010]
R&D Projects: GA MŠMT(CZ) LC06077; GA AV ČR KAN200520801; GA MŠMT(CZ) LC06061
Institutional research plan: CEZ:AV0Z40550506
Keywords : human thymidine phosphorylase * phosphorylase inhibition * phosphonate nucleosides
Subject RIV: CC - Organic Chemistry
http://irt2010.univ-lyon1.fr
A series of structurally diverse nucleoside phosphonic acids were tested for inhibition of human thymidine phosphorylase from two sources. Some inhibitors acting at submicromolar level were selected as lead structures for further evaluation.
Permanent Link: http://hdl.handle.net/11104/0192731
Number of the records: 1