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Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study
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SYSNO ASEP 0353420 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Porcine insulin receptor substrate 4 (IRS4) gene: cloning, polymorphism and association study Author(s) Masopust, Martin (UZFG-Y) RID
Vykoukalová, Z. (CZ)
Knoll, Aleš (UZFG-Y)
Bartenschlager, H. (DE)
Mileham, A. (US)
Deeb, N. (US)
Rohrer, G. A. (US)
Čepica, Stanislav (UZFG-Y) RIDSource Title Molecular Biology Reports. - : Springer - ISSN 0301-4851
Roč. 38, - (2010), 2611-2617Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords PCR cloning ; Polymorphism ; IRS4 Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA523/07/0353 GA ČR - Czech Science Foundation (CSF) GAP502/10/1216 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000289257100050 DOI 10.1007/s11033-010-0402-x Annotation Using PCR and inverse PCR techniques we obtained a 4,498 bp nucleotide sequence FN424076 encompassing the complete coding sequence of the porcine insulin receptor substrate 4 (IRS4) gene and its proximal promoter. The 1,269 amino acid porcine protein deduced from the nucleotide sequence shares 92% identity with the human IRS4 and possesses the same domains and the same number of tyrosine phosphorylation motifs as the human protein. We detected substitution FN424076:g.96C<G in the promoter region that segregates in Meishan and a synonymous substitution FN424076:g.1829T<C in the coding sequence with allele C present only in Meishan. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2012
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