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Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs
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SYSNO ASEP 0353069 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs Author(s) Usvald, Dušan (UZFG-Y)
Vodička, Petr (UZFG-Y) ORCID
Hlučilová, Jana (UZFG-Y) RID, ORCID
Procházka, Radek (UZFG-Y) RID, ORCID
Motlík, Jan (UZFG-Y) RID, ORCID
Kuchorova, K. (CZ)
Johe, K. (US)
Marsala, S. (US)
Scadeng, M. (US)
Kakinohana, O. (US)
Navarro, R. (US)
Santa, M. (SK)
Hefferan, M. P. (US)
Yaksh, T.L. (US)
Marsala, M. (US)Source Title Cell Transplantation. - : Sage - ISSN 0963-6897
Roč. 19, č. 9 (2010), s. 1103-1122Number of pages 20 s. Language eng - English Country US - United States Keywords minipigs ; human spinal stem cells ; analysis Subject RIV FH - Neurology CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000285120400004 DOI 10.3727/096368910X503406 Annotation In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and corresponding improvement in ambulatory function. In the present study, we characterized the optimal dosing regimen and safety profile of human spinal stem cells (HSSC) when grafted into the lumbar spinal cord segments of naive immunosuppressed minipigs Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2011
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