Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha

Number of the records: 1

1.

SYSNO ASEP	0352926
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis and Biochemical Characterization of a Series of 17alpha-Perfluoroalkylated Estradiols as Selective Ligands for Estrogen Receptor alpha
Author(s)	Eignerová, B. (CZ) Sedlák, David (UMG-J)_RID Dračínský, Martin (UOCHB-X)_{RID, ORCID} Bartůněk, Petr (UMG-J)_RID Kotora, Martin (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	Journal of Medicinal Chemistry. - : American Chemical Society - ISSN 0022-2623 Roč. 53, č. 19 (2010), s. 6947-6953
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	estrogen receptor ; estradiols ; selective ligands
Subject RIV	CC - Organic Chemistry
R&D Projects	LC06077 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA400550609 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000282544800012
DOI	10.1021/jm100563h
Annotation	Synthesis of a new class of potent and selective ligands for estrogen receptor alpha represented by a series of 17alpha-substituted estradiolsbearing lipophilic perfluoroalkyl chains.These estradiols were synthetized by Ru-catalyzed cross metathesis reactions.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2011

Number of the records: 1